Table S1 - The <em>PLIN4</em> Variant rs8887 Modulates Obesity Related Phenotypes in Humans through Creation of a Novel miR-522 Seed Site

Additional significant associations observed for baseline and interaction association analyses. Results of meta-analysis in FOS and GOLDN performed using a Dominant Model. P-values for anthropometrics were adjusted for sex, age, smoking, physical activity (GOLDN only), alcohol use, diabetes, beta-blockers, calories from fat, PUFA n3 and n6, and estrogen and menopausal status (FOS only) in women. Lipid and glucose p-values where also adjusted for BMI and cholesterol medications. Gene by diet interaction for meta-analysis of FOS and GOLDN. Interactions between PLIN4 variants and dietary PUFA n3 and n6 were included in a multivariate regression model as continuous variables. Values in the top table are for main effect analyses, and the bottom table for interactions analyses. (DOC)本研究在基线关联分析与交互关联分析中均观察到额外的显著关联。针对FOS与GOLDN队列开展的荟萃分析（meta-analysis）结果基于显性模型（Dominant Model）计算所得。女性人群的人体测量学指标（anthropometrics）P值已针对以下协变量进行校正：性别、年龄、吸烟情况、体力活动（仅GOLDN队列）、饮酒情况、糖尿病状态、β受体阻滞剂（beta-blockers）使用情况、脂肪供能占比、多不饱和脂肪酸n-3与n-6（PUFA n3 and n6）摄入量，以及雌激素水平与绝经状态（仅FOS队列）。脂代谢与血糖相关的P值则额外校正了身体质量指数（BMI）与胆固醇用药（cholesterol medications）情况。本部分针对FOS与GOLDN队列的荟萃分析开展了基因-膳食交互分析：将PLIN4（Perilipin 4）变异体与膳食多不饱和脂肪酸n-3、n-6的交互项作为连续变量纳入多元回归模型（multivariate regression model）。上方表格结果为主效应分析（main effect analyses）结果，下方表格结果为交互分析（interactions analyses）结果。（DOC）