Neurological Severity Score in Congenic SOD1 G93A mice: Categorical Analysis of Average Number of Days at Score by Treatment Group.1,2

1Testing Terms: Scores for Control (unaltered Jello®) and Drug (25 mg/kg methylene blue daily) are given as mean number of days spent within each severity category. P value lists the probability of obtaining, by chance alone, a value greater than the one computed if the score frequencies are the same for both treatment groups at group size minus one degree of freedom (test term description taken from the JMP® 7.0.1 Help file).2Refer to Material and Methods for a detailed description of assignment of neurological scores. Neurological disease severity increases from 0–6. Score 0 is asymptomatic. Score 6 is surrogate endpoint.

1. 测试指标：对照组（未改动的吉露®（Jello®）果冻）与药物组（每日25 mg/kg亚甲蓝（methylene blue））的评分以各严重程度分级内的平均停留天数形式给出。P值表示：当两组治疗的评分频率相同时，仅通过随机误差得到大于当前计算所得统计量的概率，检验自由度为样本量减1（本次测试术语说明摘自JMP® 7.0.1帮助文件）。2. 神经功能评分的具体赋值规则请参照材料与方法部分。神经系统疾病严重程度随评分0至6递增：评分为0时无临床症状；评分为6则为替代终点（surrogate endpoint）。