CLIP-seq to identify transcriptome-wide TDP-43-RNA binding sites in 293HEK FlipIn cells. CLIP-seq to identify transcriptome-wide TDP-43-RNA binding sites in 293HEK FlipIn cells

This experiment identified transcriptome-wide TDP-43-RNA binding sites in 293 Hek FlipIn cells. The TDP-43 variant submitted here have varying specificity in binding and deviate from the WT TDP-43 binding pattern in dependence of their reduced propensity to phase separate.

本实验在293 HEK FlipIn细胞中鉴定了转录组范围的TDP-43与RNA结合位点。本次提交的TDP-43变体在RNA结合特异性上存在差异，其结合模式相较于野生型（WT）TDP-43发生偏离，且该偏离与其相分离倾向的降低相关。