Association between PIV and probable depression.

This study explored the non-linear relationship between pan-immune inflammation value (PIV) and probable depression using NHANES data (2005–2018, n = 27,049). Restricted cubic spline analysis identified an optimal PIV cutoff (5.74). Weighted logistic regression revealed that individuals with PIV > 5.74 had 14% higher risk of probable depression (OR=1.14, 95% CI:1.02–1.28). Gender-stratified analyses showed significant PIV and probable depression associations in females (OR=1.20, 95% CI:1.03–1.40) but not in males. In males, higher PIV interacted with age, education, and alcohol consumption to influence probable depression risk (interaction P

本研究基于2005-2018年美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）数据（样本量n=27049），探讨泛免疫炎症指标（pan-immune inflammation value, PIV）与疑似抑郁症之间的非线性关联。限制性立方样条分析（restricted cubic spline analysis）确定了PIV的最佳截断值为5.74。加权logistic回归（weighted logistic regression）分析显示，PIV＞5.74的人群罹患疑似抑郁症的风险升高14%（比值比（odds ratio, OR）=1.14，95%置信区间（confidence interval, CI）:1.02~1.28）。性别分层分析结果表明，女性群体中PIV与疑似抑郁症存在显著关联（OR=1.20，95%CI:1.03~1.40），而男性群体未观察到该关联。在男性群体中，较高的PIV水平会与年龄、受教育程度及饮酒行为产生交互作用，进而影响疑似抑郁症的发病风险（交互作用P值）