Direct Electrochemical Selenylation/Cyclization of Alkenes: Access to Functionalized Benzheterocycles

A catalyst-free, environmentally friendly, and efficient electrochemical selenylation/cyclization of alkenes has been developed with moderate to excellent yields. This selenylated transformation proceeds smoothly and tolerates a wide range of synthetically useful groups to deliver diverse functionalized benzheterocycles, including iminoisobenzofuran, lactones, oxindoles, and quinolinones. Moreover, the present synthetic route could also be readily scaled up to gram quantity with convenient operation in an undivided cell.本研究开发了一种无催化剂、环境友好且高效的烯烃电化学硒化/环化反应，该反应可获得中等至优异的收率。该硒化转化过程平稳进行，可兼容多种具有合成应用价值的官能团，能够制备包括亚氨基异苯并呋喃、内酯、氧化吲哚与喹啉酮在内的多种官能团化苯并杂环化合物。此外，该合成路线可在无分隔电解池中便捷操作，轻松放大至克级规模。