rs2282679 polymorphism association with diseases and traits that have been observationally related to vitamin D levels.

Regression models were adjusted for age and sex. Analyses of disease-related traits were performed on both adult and youth CaMos cohorts; analyses of diseases were restricted to the CaMos adult cohort only. M-dashes indicate that summary data were not publically available.∫Measurement change for disease-related traits and OR for diseases. Change in measurement of disease-related trait is per each additional copy of the risk allele. All continuous variables were inspected for normality, and outliers (∥The natural logarithm was used.¶Effect estimates excluding participants with diabetes were similar for fasting glucose, −0.013 (95% CI −0.050, 0.023), p = 0.47, and for fasting insulin, −0.034 (95% CI −0.075, 0.007), p = 0.10.*ICBP had available GWAS data only on blood pressure measurements, not on hypertension; no association was found for systolic blood pressure, diastolic blood pressure, mean arterial pressure, and pulse pressure.|This effect estimate provided by METASTROKE is for overall ischemic stroke, which does not include TIA.rs2282679 polymorphism association with diseases and traits that have been observationally related to vitamin D levels.

回归模型已针对年龄与性别进行校正。针对疾病相关性状的分析同时覆盖成人与青少年CaMos队列；而针对疾病的分析仅限定于CaMos成人队列。M破折号（M-dashes）表示对应条目无公开汇总数据。∫ 本部分呈现疾病相关性状的测量变化量与疾病的比值比（Odds Ratio, OR）。疾病相关性状的测量变化量以风险等位基因每额外增加1份为计算单位。对所有连续变量进行了正态性检验，并针对异常值进行了处理（∥ 本研究采用自然对数转换。¶ 排除糖尿病参与者后，空腹血糖的效应估计值为−0.013（95%置信区间：−0.050, 0.023），p=0.47；空腹胰岛素的效应估计值为−0.034（95%置信区间：−0.075, 0.007），p=0.10。* ICBP仅拥有血压测量值的全基因组关联研究（Genome-Wide Association Study, GWAS）数据，未包含高血压相关数据；未发现收缩压、舒张压、平均动脉压及脉压存在显著关联。| 由METASTROKE提供的该效应估计值针对整体缺血性卒中，未纳入短暂性脑缺血发作（Transient Ischemic Attack, TIA）。rs2282679多态性与已通过观察性研究证实与维生素D水平相关的疾病及性状存在关联。