RNASeq whole blood of Dutch 500FG cohort

Expression levels from bulk whole blood from 96 individuals within the 500FG cohort. The aim of the 500FG project is to characterize the interaction between the genetic background of the host, the microbiome composition of different niches, and the consequences on an array of physiological functions: the immune response against important human pathogens, thrombocyte function, and in a subgroup of individuals the cognitive function of the brain. These aims are approached by a combination of advanced -omics technology, cutting edge functional tests (immune tests, functional brain MRI, etc) and systems biology-based bioinformatics. Overall design: Quantification of gene expression in bulk whole blood using paired end RNA Sequencing

本数据集包含500FG队列（500FG cohort）中96名个体的批量全血（bulk whole blood）基因表达水平数据。500FG项目旨在解析宿主遗传背景、不同生态位微生物组组成之间的相互作用，及其对一系列生理功能的影响：包括针对重要人类病原体的免疫应答、血小板功能，以及部分个体亚组的大脑认知功能。该项目通过整合先进组学（-omics）技术、前沿功能实验（免疫实验、功能性脑磁共振成像等）以及基于系统生物学的生物信息学（systems biology-based bioinformatics）手段来实现上述研究目标。整体实验设计为：采用双端RNA测序（paired end RNA Sequencing）对批量全血中的基因表达进行定量分析。