DNA methylation profiling of the Biomarkers of Aging Consortium Cohort

We generated DNA methylation profiles of 500 diverse individuals to enable to construction and validation of DNA methylation biomarkers of aging. We selected 500 subjects to generate a cohort that was evenly divided between male and female, and represented a broad range of ages and race/ethnicity. DNA isolated from the blood of these subjects was profiled with the Illumina Infinium MethylationEPIC v2.0 array.

本研究生成了500名不同个体的DNA甲基化（DNA methylation）谱图，以用于衰老相关DNA甲基化生物标志物（biomarker）的构建与验证。我们选取500名受试者构建队列，该队列男女比例均衡，覆盖了广泛的年龄跨度与种族/族裔分布。本研究采用Illumina Infinium MethylationEPIC v2.0芯片，对从上述受试者血液中分离得到的DNA进行了甲基化谱检测。