Early-Stage Mycosis Fungoides: Searching for biomarkers associated with advanced stage progression Item (Supplementary data)

This study shows that the microenvironment and probably the phenotype of neoplastic T-cells of early-stage MF samples from MF-patients who suffered progression or remained stable is different. Moreover, we propose that the overexpression of CD30, CXCL13 and BIRC3 in early-stage MF is related to progression. Further spatial transcriptomics studies and single cell analysis are needed to corroborate our findings, in addition to allowing a much more specific separation between the microenvironment of lesions and tumour cells.

本研究显示，出现疾病进展或病情维持稳定的蕈样肉芽肿（Mycosis Fungoides, MF）患者的早期MF样本中，其肿瘤微环境以及肿瘤性T细胞的表型可能存在差异。此外，本研究提出，早期MF样本中CD30、CXCL13与BIRC3的过表达与疾病进展相关。后续需开展进一步的空间转录组学（spatial transcriptomics）研究与单细胞分析，以佐证本研究结论，同时实现病灶微环境与肿瘤细胞间更为精准的区分。