Additional file 1: of Brain transcriptome analysis of a familial Alzheimer’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production

Genes differentially expressed between heterozygous mutant and wild type brains at 6 months. Lists the genes identified as differentially expressed between the brains of heterozygous psen1Q96_K97del mutant fish and the brains of their wild type siblings at an age of 6 months. Genes are ranked according to FDR-corrected p-value. Only genes with a FDR-corrected p-value less than 0.05 are shown. “FC” denotes fold change. “DE” denotes differential expression. For DE_Direction, “1” denotes increased expression in the mutant and “-1” denotes decreased expression in the mutant. (XLSX 39 kb)

本数据集收录6月龄杂合突变体与野生型脑组织间的差异表达基因。具体收录了6月龄psen1Q96_K97del杂合突变型鱼类与其野生型同窝个体脑组织中鉴定得到的差异表达基因。所有基因依据经错误发现率（FDR, False Discovery Rate）校正后的p值进行排序，仅展示经FDR校正后p值小于0.05的基因。其中，“FC”代表折叠变化（Fold Change），“DE”代表差异表达（Differential Expression）。在DE_Direction字段中，“1”表示突变体脑组织内基因表达上调，“-1”表示突变体脑组织内基因表达下调。本数据集为XLSX格式，文件大小39 kb。