Dataset for: CGF Induces ROS-Mediated Metabolic Reprogramming and Mitochondrial Dysfunction to Suppress Colorectal Cancer Progression

Colorectal cancer ranks among the most lethal malignancies worldwide, highlighting the urgent need for innovative therapeutic strategies. Natural products have emerged as promising anticancer agents due to their biological activities and favorable safety profiles. Here, the anti-tumor effects and molecular mechanisms of Cya-Gly-Fer (CGF), a natural compound derived from purple sweet potato, are systematically characterized for the first time. CGF significantly inhibits proliferation, migration, and invasion of CRC cell lines in a dose-dependent manner. Integrated transcriptomics and metabolomics reveal that CGF broadly rewires CRC metabolic circuits. This dataset contains the untargeted metabolomics data supporting these findings.结直肠癌是全球致死率最高的恶性肿瘤之一，凸显了开发创新治疗策略的迫切需求。天然产物因其多样的生物活性与优良的安全性特征，已成为颇具潜力的抗癌候选药物。本研究首次对源自紫薯的天然化合物Cya-Gly-Fer（CGF）的抗肿瘤作用与分子机制进行了系统性表征。CGF可通过剂量依赖方式显著抑制结直肠癌细胞系的增殖、迁移与侵袭能力。整合转录组学与代谢组学分析显示，CGF可广泛重塑结直肠癌细胞的代谢通路。本数据集包含支撑上述研究发现的非靶向代谢组学数据。