Curated and harmonised transcriptomics datasets of interstitial lung disease patients

The datasets uploaded within this record contain transcriptomics data of interstitial lung disease patients retrieved from the NCBI Gene Expression Omnibus and European Nucleotide Archive (ENA) repositories. Overall, we retrieved 30 transcriptomics datasets, produced through both DNA microarrays and RNA-Sequencing technologies, along with relative meta-data tables. After data collection, all the datasets underwent meta-data curation and harmonisation, data quality check, and pre-processing with standardised procedures. Beside, data model was created in order to homogenise the phenotypic data enabling the comparability across the datasets. In addition, for every study included in this data release we provide tables of differentially expressed genes and co-expression network models of IPF samples and healthy counterparts deriving from both RNA-seq and DNA microarrays.

上传至本记录的数据集包含从NCBI基因表达综合数据库（Gene Expression Omnibus，GEO）与欧洲核苷酸档案馆（European Nucleotide Archive，ENA）获取的间质肺疾病患者转录组学数据。本研究共获取30套转录组学数据集，涵盖基于DNA微阵列与RNA测序技术生成的数据，同时附带相关元数据表。数据收集完成后，所有数据集均通过标准化流程完成元数据整理与统一化处理、数据质量校验及预处理工作。此外，本研究构建了数据模型以实现表型数据的同质化处理，确保不同数据集间具备可比性。针对本次数据发布中纳入的所有研究，我们提供了基于RNA-seq与DNA微阵列技术得到的特发性肺纤维化（Idiopathic Pulmonary Fibrosis，IPF）样本及其健康对照的差异表达基因表与共表达网络模型。