Adverse Outcome Pathway on antagonist binding to PPARα leading to body‑weight loss
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The present AOP describes antagonistic chemical binding to the peroxisome proliferator-activated receptor α (PPARα), resulting in preferential binding a co-repressor to the overall PPARα signalling complex causing a chain of events that includes: antagonism of PPARα nuclear signalling, decreased transcriptional expression of PPARα-regulated genes...
本不良反应通路（Adverse Outcome Pathway，AOP）阐述了拮抗类化合物与过氧化物酶体增殖物激活受体α（PPARα）的结合过程：该结合会促使辅阻遏蛋白优先结合至完整的PPARα信号复合物，进而触发一系列级联事件，其中涵盖PPARα核信号通路的拮抗作用，以及PPARα调控基因的转录表达水平下调……
