Rates.

A) The table shows the rate constants used by the simulation. During optimization, kA, kE, kL, and dE were varied, and kM was varied in one case. Column “streamlined with slow maturation” is the streamlined model with kM = 5.5 fixed. Column “multiple-lipoplex with fast maturation” is the multiple-lipoplex model with kM = 9.23 fixed to the value from literature. Column “multiple-lipoplex with slow maturation” is the multiple-lipoplex model with kM varied (optimized). The literature values are described in more detail in the File S1. B) The last 5 rows are the experimental data used as a goal in optimization.Rates.