Rates.

A) The table shows the rate constants used by the simulation. During optimization, kA, kE, kL, and dE were varied, and kM was varied in one case. Column “streamlined with slow maturation” is the streamlined model with kM = 5.5 fixed. Column “multiple-lipoplex with fast maturation” is the multiple-lipoplex model with kM = 9.23 fixed to the value from literature. Column “multiple-lipoplex with slow maturation” is the multiple-lipoplex model with kM varied (optimized). The literature values are described in more detail in the File S1. B) The last 5 rows are the experimental data used as a goal in optimization.Rates.

A) 该表格列出了模拟所用的速率常数。优化过程中，kA、kE、kL及dE均设为可变参数，另有一组实验中kM同样为可变参数。列标为"streamlined with slow maturation（慢速成熟简化模型）"的列，对应将kM固定为5.5的简化模型；列标为"multiple-lipoplex with fast maturation（快速成熟多脂质复合物（multiple-lipoplex）模型）"的列，对应将kM固定为文献报道值9.23的多脂质复合物模型；列标为"multiple-lipoplex with slow maturation（慢速成熟多脂质复合物模型）"的列，对应kM为可变参数（经优化）的多脂质复合物模型。文献采用的参数值详细说明见补充材料S1。B) 最后5行即为用作优化目标的实验速率数据。