STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes

We elucidated the potential role of STAT3 in the skin barrier and its effect on kallikrein-related peptidase 5 (KLK5) and serine protease inhibitor Kazal-type 5 (SPINK5) expression using a mouse model with keratinocyte-specific ablation of STAT3. Overall design: mouse model with keratinocyte-specific ablation of STAT3

本研究通过构建角质形成细胞特异性敲除信号转导与转录激活因子3（STAT3）的小鼠模型，阐明了STAT3在皮肤屏障中的潜在作用，以及其对激肽释放酶相关肽酶5（KLK5）与Kazal型丝氨酸蛋白酶抑制剂5（SPINK5）表达的影响。实验整体设计：采用角质形成细胞特异性敲除STAT3的小鼠模型。