CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH N1=C(C(=O)C=CN1c2cccc(c2)C(F)(F)F)c3ccnn3c4c(cccc4)F, micromolar IC50=0.07

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH N1=C(C(=O)C=CN1c2cccc(c2)C(F)(F)F)c3ccnn3c4c(cccc4)F, micromolar IC50=0.07 Descriptor: 3-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Brunner, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人源磷酸二酯酶10（human phosphodiesterase 10）与配体N1=C(C(=O)C=CN1c2cccc(c2)C(F)(F)F)c3ccnn3c4c(cccc4)F的晶体结构，该配体的半最大抑制浓度（IC50）为0.07微摩尔。配体标识：3-[1-(2-氟苯基)-1H-吡唑-5-基]-1-[3-(三氟甲基)苯基]哒嗪-4(1H)-酮，体系包含镁离子、锌离子等。作者：Joseph C、Benz J、Flohr A、Brunner M、Rudolph M.G.。提交日期：2022-02-01；发布日期：2022-10-12；最后更新日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.3埃（Å）。引用文献：《人源磷酸二酯酶10复合物的晶体结构》（Crystal Structure of a human phosphodiesterase 10 complex），待发表。