single nucleus RNA-seq of mouse left ventricle after aldosterone-salt treatment

Mice received aldosterone plus high salt diet to induce a HFpEF-like phenotype. Single nucleus RNAseq from left ventricular tissue was performed using a 10x genomics platform.

研究人员给小鼠饲喂醛固酮（aldosterone）联合高盐饮食，以诱导出射血分数保留型心力衰竭（Heart Failure with Preserved Ejection Fraction，HFpEF）样表型。本研究采用10x Genomics平台对左心室组织进行了单细胞核RNA测序（single nucleus RNAseq）。