DataSheet2_Nano-Sonosensitized Sonodynamic Nanomedicine Augments Tumor-Selective Catalytic Tumor Eradication.ZIP

Inspired by the distinct metabolic pathway of tumor cells, here a new anti-cancer therapy (i.e., Cu-TCPP(Fe) metal-organic frameworks (MOFs) with sonosensitizer for sonodynamic therapy (SDT) and tumor microenvironment (TME)-specific release of copper/iron for chemical catalysis) is introduced and verified. Upon exposure to ultrasound, the porphyrin structure in the MOFs yields reactive oxygen species (ROS), and the copper/iron induces the Fenton reaction in the TME existing H2O2 and acid. Thus, highly toxic ROS are generated through these TME-specific reactions to trigger the apoptosis and death of tumor cells. The current work paves a new avenue to design SDT with catalytic nanomedicine for the selective and effective treatment of tumors.

受肿瘤细胞独特的代谢通路启发，本研究提出并验证了一种新型抗癌疗法：即搭载声敏剂（sonosensitizer）的Cu-TCPP(Fe)金属有机框架（metal-organic frameworks, MOFs），可用于声动力治疗（sonodynamic therapy, SDT），并能在肿瘤微环境（tumor microenvironment, TME）中特异性释放铜/铁离子以实现化学催化。当受到超声辐照时，该MOFs中的卟啉结构会产生活性氧（reactive oxygen species, ROS）；而铜、铁离子可在肿瘤微环境中已存在的过氧化氢与酸性条件下触发芬顿（Fenton）反应。借此，通过这些肿瘤微环境特异性反应可生成高毒性活性氧，进而诱导肿瘤细胞凋亡与死亡。本研究为设计兼具催化功能的纳米药物用于肿瘤选择性高效治疗开辟了全新途径。