ROSMAP meQTL Results for Astrocytes with CpGs

This dataset contains methylation quantitative trait loci (meQTL) results for the following study: "regionalpcs improve discovery of DNA methylation associations with complex traits" Tiffany Eulalio*1, Min Woo Sun1, Olivier Gevaert1, Michael D. Greicius2, Thomas J. Montine3, Daniel Nachun*‡3, Stephen B. Montgomery*‡1,3 ‡ These authors contributed equally as senior authors * Corresponding authors: Tiffany Eulalio ([e-mail]), Daniel Nachun ([e-mail]), Stephen B. Montgomery ([e-mail]) Author affiliations: 1. Department of Biomedical Data Science, Stanford University, Stanford, CA 2. Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA 3. Department of Pathology, Stanford University, Stanford, CA Dataset description: This dataset contains QTL results generated from FastQTL, organized by region type (full gene, gene body, preTSS, and promoters) and summary types (averages and regional principal components). Contents: Parquet tar files: These compressed archives contain output files in Parquet format from FastQTL, split by chromosome. parquet1 includes chromosomes 1-10, and parquet2 includes chromosomes 11-22. cis_qtl_summary_stats.csv: Provides summary statistics for each phenotype-variant pair, including effect sizes, p-values, TSS distances, and additional details. cis_qtl.signif_pairs.csv: Contains the significant QTL results identified by FastQTL. cis_qtls.time_to_run.txt: Reports the running time for FastQTL analysis. cis_qtls.cis_qtl.txt.gz: Contains comprehensive results for all cis QTLs. This dataset is intended to support replication and further exploration of QTL associations across different genomic regions and summary methods.本数据集包含以下研究的甲基化数量性状位点（methylation quantitative trait loci, meQTL）分析结果： "区域主成分提升复杂性状DNA甲基化关联的发掘效能" Tiffany Eulalio*1、Min Woo Sun1、Olivier Gevaert1、Michael D. Greicius2、Thomas J. Montine3、Daniel Nachun*‡3、Stephen B. Montgomery*‡1,3 ‡ 带‡标记的作者为同等贡献的资深作者 * 通讯作者：Tiffany Eulalio（邮箱：[e-mail]）、Daniel Nachun（邮箱：[e-mail]）、Stephen B. Montgomery（邮箱：[e-mail]） 作者单位： 1. 斯坦福大学生物医学数据科学系，美国加利福尼亚州斯坦福市 2. 斯坦福大学神经病学与神经科学系，美国加利福尼亚州斯坦福市 3. 斯坦福大学病理学系，美国加利福尼亚州斯坦福市 数据集说明： 本数据集包含由FastQTL生成的数量性状位点分析结果，按区域类型（全基因区、基因本体区、转录起始位点上游区（preTSS）及启动子区）和汇总类型（平均值与区域主成分）进行组织。 数据集内容： Parquet格式Tar归档文件：此类压缩归档包含FastQTL生成的Parquet格式输出文件，按染色体拆分。parquet1包含第1至10号染色体，parquet2包含第11至22号染色体。 cis_qtl_summary_stats.csv：提供每个表型-变异对的汇总统计信息，包括效应量、p值、转录起始位点距离及其他详细信息。 cis_qtl.signif_pairs.csv：包含FastQTL鉴定得到的显著性数量性状位点关联结果。 cis_qtls.time_to_run.txt：记录FastQTL分析的运行时长。 cis_qtls.cis_qtl.txt.gz：包含所有顺式数量性状位点的完整分析结果。 本数据集旨在支持跨不同基因组区域及汇总方法的数量性状位点关联的验证与进一步探索研究。