Heidelberg BAG (HeidelBAG)

The HeidelBAG unifies structural efforts of EMBL Heidelberg and the Heidelberg University Biochemistry Center (BZH). Central to all projects are large assemblies involved in chromosome organization and transcription control, in nuclear and cytoplasmic RNA regulation, in translational control by ribosome associated factors or further on in protein targeting, membrane protein insertion or post-translational modification. While Eric Stebbins from DKFZ has left the BAG, Jirka Peschek from BZH will join and adds projects on tRNA ligases and interactors. Nearly all projects make use of integrated structural biology techniques combined with complementary biophysical, biochemical and cell biological approaches, a strategy that warranties the continuous success of the BAG. More and more pathological implications of the studied central cellular processes come into focus. In the 1st year of the proposal the BAG reports on 17 publications and 43 PDB entries and many unpublished results.

HeidelBAG整合了欧洲分子生物学实验室（EMBL）海德堡分部与海德堡大学生物化学中心（BZH）的结构生物学研究力量。本协作组的所有核心项目均以大型复合物为研究核心，涵盖染色体组装与转录调控、核质RNA调控、核糖体相关因子介导的翻译调控，以及蛋白质靶向、膜蛋白插入与翻译后修饰等多个细胞过程。
此前来自德国癌症研究中心（DKFZ）的Eric Stebbins已离开该协作组，而来自BZH的Jirka Peschek即将加入，其研究方向为tRNA连接酶及其互作蛋白相关项目。
几乎所有项目均采用整合结构生物学技术，并结合互补的生物物理、生物化学与细胞生物学研究手段，这一研究策略保障了该协作组的持续产出与成功。
当前研究所聚焦的核心细胞过程的病理关联愈发受到重视。在本项目立项的首年，该协作组已发表17篇学术论文，获得43个蛋白质数据库（Protein Data Bank, PDB）条目，并产出大量未公开的研究成果。