The effect of prolonged G-quadruplex stabilization on the functions of human cells

Guanine-rich DNA sequences have a propensity to form G-quadruplex structures. We found that G-quadruplex stabilization does not compromise genome integrity. However, it can induce persistent alterations in the transcriptomic profile of human cells.

富鸟嘌呤DNA序列具有形成G-四链体（G-quadruplex）结构的倾向。我们发现，G-四链体的稳定化并不会损害基因组完整性。然而，该过程可诱导人类细胞转录组谱发生持续性改变。