Bisacremines A–D, Dimeric Acremines Produced by a Soil-Derived Acremonium persicinum Strain

Four dimeric acremines, bisacremines
A–D (1–4), with a novel carbon
skeleton and a new monomer, acremine T (5), were obtained
from cultures of the soil-derived fungus Acremonium
persicinum SC0105. Their structures were characterized
by analysis of spectroscopic data, ECD/TDDFT computations, and X-ray
diffraction. Compounds 1 and 2 exhibited
weak cytotoxicity against HeLa cells, and 2 also showed
modest activity against A549 and HepG2 cells.

从土壤来源真菌桃色顶孢霉（Acremonium persicinum）SC0105的发酵培养物中，分离得到4个具有全新碳骨架的二聚体阿克雷菌素类化合物——双阿克雷菌素A-D（1~4），以及1个新的单体阿克雷菌素T（5）。所有化合物的结构均通过光谱数据分析、电子圆二色谱（ECD, Electronic Circular Dichroism）/含时密度泛函理论（TDDFT, Time-Dependent Density Functional Theory）计算以及X射线衍射完成表征。其中化合物1与2对海拉（HeLa）细胞表现出微弱细胞毒性；化合物2同时对A549细胞与HepG2细胞展现出中等强度的抗肿瘤活性。