Chemical restraint of coatis by the association of Detomidine, Tiletamine and Zolazepam, in allometrically scaled dosages

ABSTRACT Ten free-living adult coatis (two males and eight females) were chemically restrained with "ZAD-50", a concentrated formulation prepared with the dehydrated content of a Zoletil/50® vial diluted with 0.25mL of 1% atropine, 0.265mL of Dormiun-V®, and 2.2mL of distilled water, being exactly 3.0mL. The formula was administered to each animal previously captured and physically contained with a net. The loss of righting reflex (RR) occurred at 2.3±0.8 minutes post-injection (MPI), with anesthesia beginning at 4.4±2.7 MPI. Myorelaxant and analgesia were considered excellent at all moments of the evaluation. Conscious reactions were observed at 78.7±22.2 MPI, the return of the RR occurred at 101 ± 18 MPI, and normal ambulation was acquired at 137.0±31.0 MPI. The mean values of physiological parameters measured every 10 minutes between 10 and 50 MPI were 152.2 heartbeats per minute for heart rate, 66.4 respiratory movements per minute for respiratory rate, 39.2oC for rectal temperature, 86.2% for SpO2 and 14.6 mmHg for systolic blood pressure. In the same times, the EEG registered sinus rhythm. No adverse reactions were observed, and the assessed vital parameters remained compatible with the state of chemical restraint.

摘要：10只野生成年长鼻浣熊（2雄8雌）采用ZAD-50进行化学保定。该制剂为浓缩配方，由1瓶Zoletil/50®的冻干内容物，加入0.25mL 1%阿托品、0.265mL Dormiun-V®以及2.2mL蒸馏水配制而成，总容积恰好为3.0mL。所有事先经网捕并物理保定的受试动物均接受该制剂注射。翻正反射（righting reflex, RR）于注射后2.3±0.8分钟（minutes post-injection，MPI）消失，麻醉诱导于注射后4.4±2.7分钟启动。所有评估时段的肌松与镇痛效果均评定为优异。意识恢复反应于注射后78.7±22.2分钟出现，翻正反射恢复于注射后101±18分钟，正常行走能力于注射后137.0±31.0分钟恢复。在注射后10至50分钟期间，每10分钟测定的生理参数均值如下：心率为152.2次/分钟，呼吸频率为66.4次/分钟，直肠温度为39.2℃，脉搏血氧饱和度（SpO2）为86.2%，收缩压为14.6mmHg。同期脑电图（electroencephalogram, EEG）监测显示窦性节律。未观察到不良反应，且评估的生命体征参数始终与化学保定状态相符。