Comparative genomics of sex-determination-related genes reveals shared evolutionary patterns between bivalves and mammals, but not fruit flies

The molecular basis of sex determination (SD), while being extensively studied in model organisms, remains poorly understood in many animal groups. Bivalves, a diverse class of molluscs with a variety of reproductive modes, represent an ideal yet challenging clade for investigating SD and the evolution of sexual systems. However, the absence of a comprehensive framework has limited progress in this field, particularly regarding the study of sex-determination related genes (SRGs). In this study, we performed a genome-wide sequence evolutionary analysis of the Dmrt, Sox, and Fox gene families in more than 40 bivalve species. For the first time, we provide an extensive and phylogenetic-aware dataset of these SRGs, and we find support to the hypothesis that Dmrt-1L and Sox-H may act as primary sex-determining genes, by showing their high levels of sequence diversity within the bivalve genomic context. To validate our findings, we studied the same gene families in two well-characterized syst..., , # Comparative genomics of sex-determination-related genes reveals shared evolutionary patterns between bivalves and mammals, but not fruit flies

Dataset DOI: [10.5061/dryad.0cfxpnwfj](10.5061/dryad.0cfxpnwfj)

In this repository you will find the files of main results generated by the analyses in the research paper:

**[Nicolini F](https://github.com/filonico), Nuzhdin S,** **[Ghiselli F](https://github.com/fghiselli),** **[Luchetti A](https://github.com/andluche), Milani L**. *Comparative genomics of sex-determination-related genes reveals shared evolutionary patterns between bivalves and mammals, but not fruit flies.*

Visit our research group website, **[EVO·COM](https://sites.google.com/view/evo-com-unibo)**!

## What you can find here

This repository contains three different directories, one per each analysed dataset:

* in `bivalve_results.tar.gz` you can find results for the dataset of bivalve genomes and transcriptomes;
* in `mammal_results.tar.gz` you can find results for the...,

性别决定（sex determination, SD）的分子基础虽已在模式生物中得到广泛研究，但在诸多动物类群中仍未被充分阐释。双壳类是一类生殖方式多样的软体动物纲，是探究性别决定与性系统演化的理想却极具挑战性的演化支。然而，缺乏全面的研究框架限制了该领域的研究进展，尤其是在性别决定相关基因（sex-determination related genes, SRGs）的研究方面。本研究对40余种双壳类物种的Dmrt、Sox及Fox基因家族开展了全基因组序列演化分析。我们首次构建了涵盖上述性别决定相关基因的大规模且兼顾系统发育信息的数据集，并通过分析其在双壳类基因组背景下的高水平序列多样性，为Dmrt-1L与Sox-H可能作为初级性别决定基因的假说提供了支持证据。为验证本研究发现，我们在两种已被充分表征的[原文内容截断]。

性别决定相关基因的比较基因组学研究揭示双壳类与哺乳类共有的演化模式，而非果蝇

数据集DOI：[10.5061/dryad.0cfxpnwfj](10.5061/dryad.0cfxpnwfj)

本仓库包含本研究论文分析所得的主要结果文件：

**[Nicolini F](https://github.com/filonico)、Nuzhdin S、** **[Ghiselli F](https://github.com/fghiselli)、** **[Luchetti A](https://github.com/andluche)、Milani L**。《性别决定相关基因的比较基因组学研究揭示双壳类与哺乳类共有的演化模式，而非果蝇》

访问我们的研究团队网站：**[EVO·COM](https://sites.google.com/view/evo-com-unibo)**！

## 本仓库内容说明

本仓库包含三个不同目录，分别对应每一个分析数据集：
* 在`bivalve_results.tar.gz`中，可获取双壳类基因组与转录组数据集的分析结果；
* 在`mammal_results.tar.gz`中，可获取哺乳类数据集的分析结果；[原文内容截断]