Dexamethasone-stimulated DNA methylation in peripheral blood

Genome-wide DNA methylation profiling was conducted on 199 individuals (398 samples, pre- and post-treatment with Dex) recruited at the Max Planck Institute of Psychiatry (MPIP). Whole blood samples were analyzed using the Illumina EPIC v1 DNA Methylation Beadchip to obtain comprehensive DNA methylation profiles. Bisulphite converted DNA from the 398 samples were hybridised to the Illumina EPIC v1 methylation Beadchip .

本研究针对马克斯·普朗克精神病学研究所（Max Planck Institute of Psychiatry, MPIP）招募的199名受试者开展全基因组DNA甲基化谱分析，共获得398份样本，涵盖地塞米松（Dex）处理前与处理后的样本。采用Illumina EPIC v1 DNA甲基化芯片（Illumina EPIC v1 DNA Methylation Beadchip）对所有全血样本进行分析，以获取全面的DNA甲基化谱。将398份样本的亚硫酸氢盐转化DNA（Bisulphite converted DNA）与该Illumina EPIC v1甲基化芯片进行杂交。