Nanoparticle Protein Coronas Differentially Interrogate Proteomes with Superior Performance Compared to Conventional Deep Proteome Workflows

The superior performance of a multiple NP workflow was shown compared to high-complexity, state-of-the-art, high-pH fractionation strategies in terms of depth and precision. We also evaluate the link between the physicochemical properties of NPs and their differential protein selectivity.

研究表明，相较于高复杂度、当前顶尖的高pH分级分离策略，多纳米颗粒（Nanoparticle, NP）工作流在覆盖深度与精度层面展现出更优性能。本研究同时评估了纳米颗粒的理化特性与其差异化蛋白选择性之间的关联。