Effect of sirt6 deficiency on gene expression in zebrafish at 3 dpf

To investigate the underlying mechanisms of sirt6 in the regulation of HSCs and neutrophils lineage expansion in zebrafish. Overall design: We generated a sirt6 mutant zebrafish line using CRISPR/Cas9 methods

本研究旨在探究沉默信息调节因子6（SIRT6）调控斑马鱼造血干细胞（Hematopoietic Stem Cells, HSCs）与中性粒细胞谱系扩增的潜在机制。整体实验设计：我们采用CRISPR/Cas9技术构建了sirt6突变型斑马鱼品系。