Table 4_Antimicrobial resistance profiles of Staphylococcus spp. and Escherichia coli isolated from dogs and cats in Seoul, South Korea during 2021–2023.pdf

We investigated the antimicrobial resistance (AMR) rates and profiles of Staphylococcus spp. and Escherichia coli (E.coli) isolated from dogs and cats in Seoul, South Korea during 2021–2023. We analyzed AMR profiles of Staphylococcus spp. and E. coli isolated from 2,180 samples (1,859 canine and 321 feline) collected from 36 veterinary clinics in Seoul, South Korea, as part of the Korean Veterinary Antimicrobial Resistance Monitoring System (2021–2023). A total of 484 Staphylococcus spp. isolates and 158 E. coli isolates were identified and used for AMR test. Staphylococcus spp. isolates exhibited the highest resistance to penicillin in both dogs (85%) and cats (29.81%). Multidrug-resistant (MDR) Staphylococcus spp. was more prevalent in dogs (65%) than in cats (14.42%), with three S. pseudintermedius isolates from dogs and a S. pseudintermedius isolate from a cat showing resistance to eight antibiotic classes. Methicillin-resistant S. pseudintermedius (MRSP) constituted 105 out of 284 S. pseudintermedius isolates (36.97%) in dogs and seven strains out of 14 (50%) in cats. E. coli isolates demonstrated the highest resistance to cefalexin in both dogs (61.72%) and cats (56.67%). The prevalence of MDR E. coli was higher in dogs (37.5%) than in cats (26.67%). This study highlights the concerning prevalence of AMR in commensal or potentially opportunistic pathogens from companion animals, particularly in dogs. It is crucial to promote the prudent use of antimicrobials in companion animals and ensure the ongoing monitoring of trends in antimicrobial-resistant bacteria to mitigate the selection and spread of antibiotic-resistant bacteria between humans and companion animals.

本研究针对2021—2023年韩国首尔地区犬与猫体内分离得到的葡萄球菌属（Staphylococcus spp.）及大肠杆菌（Escherichia coli, E. coli）的抗菌药物耐药性（antimicrobial resistance, AMR）发生率与耐药谱展开调查。作为韩国兽医抗菌药物耐药性监测系统（Korean Veterinary Antimicrobial Resistance Monitoring System, 2021—2023）的研究内容之一，本研究对从韩国首尔36家兽医诊所采集的2180份样本（其中1859份犬源样本、321份猫源样本）中分离得到的葡萄球菌属与大肠杆菌的耐药谱进行了分析。最终共鉴定出484株葡萄球菌属分离株与158株大肠杆菌分离株用于AMR检测。葡萄球菌属分离株在犬（85%）与猫（29.81%）群体中均对青霉素表现出最高耐药性。多重耐药（multidrug-resistant, MDR）葡萄球菌属在犬中的检出率（65%）高于猫（14.42%）；其中从犬分离得到的3株中间葡萄球菌（S. pseudintermedius）与从猫分离得到的1株中间葡萄球菌，可对8类抗菌药物产生耐药性。在犬源中间葡萄球菌分离株中，耐甲氧西林中间葡萄球菌（Methicillin-resistant S. pseudintermedius, MRSP）共计105株，占284株分离株的36.97%；在猫源分离株中，该类菌株共7株，占14株分离株的50%。大肠杆菌分离株在犬（61.72%）与猫（56.67%）群体中均对头孢氨苄（cefalexin）表现出最高耐药性。犬源多重耐药大肠杆菌的检出率（37.5%）高于猫源（26.67%）。本研究揭示了伴侣动物来源的共生菌或潜在机会致病菌中AMR的高流行率，尤其在犬群中。推广伴侣动物抗菌药物的审慎使用，并持续监测抗菌耐药菌的流行趋势，以减缓耐药菌在人类与伴侣动物间的选择与传播，具有至关重要的现实意义。