The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury II

We show that microglial gene expression patterns gradually change during RGC degeneration induced by optic nerve injury and ripasudil treatment. Examination of 2 different concentration of ripasudil treatment and vehicle treatment in Iba1-positive retinal cells.

我们的研究表明，在视神经损伤联合瑞帕舒地（ripasudil）处理诱导的视网膜神经节细胞（Retinal Ganglion Cell, RGC）变性过程中，小胶质细胞的基因表达模式会逐渐发生改变。本研究针对Iba1阳性（Iba1-positive）视网膜细胞，设置了两种不同浓度的瑞帕舒地处理组与溶剂对照处理组并开展了检测分析。