Supplementary Material for: Prodromal dementia with Lewy bodies: a case series of the 3 prodromal types from clinical practice

Prodromal dementia with Lewy bodies (DLB) refers to a state prior to the onset of dementia with clinical signs or symptoms that may indicate the future development of DLB. Prodromal symptoms can include not only cognitive deficits but also a mix of clinical features including sleep disorders, autonomic dysfunction, and neuro-psychiatric disturbances. While diagnostic criteria for the subtypes of prodromal DLB were recently published, they are largely for use in the research setting. However, these diagnostic criteria have important implications for clinical practice. Helping clinicians to recognize prodromal stages of DLB can lead to identifying deficits sooner, improved patient and family counseling, and advance care planning. This case series presents examples of the 3 subtypes of prodromal DLB – mild cognitive impairment-onset, delirium-onset, and psychiatric-onset – to help clinicians identify individuals who may be on a trajectory to develop DLB.

路易体痴呆前驱期（Prodromal dementia with Lewy bodies, DLB）指路易体痴呆发病前的阶段，此时已出现可提示未来罹患DLB风险的临床体征与症状。前驱症状不仅包括认知功能缺损，还涵盖睡眠障碍、自主神经功能紊乱及神经精神异常等多类临床特征。尽管近期已发布针对前驱DLB亚型的诊断标准，但此类标准目前主要用于科研场景。不过，这些诊断标准对临床实践亦具有重要参考价值。协助临床医师识别DLB前驱期，能够更早地发现功能缺损、为患者及家属提供更优质的咨询服务，并推进预先医疗照护规划。本病例系列展示了前驱DLB的3种亚型——轻度认知损害起病型、谵妄起病型及精神障碍起病型——以协助临床医师识别可能进展为DLB的人群。