Influenza B virus infection alters regenerative potential of alveolar type 2 pneumocytes (RNA-Seq)

Alveolar type 2 cells proliferate after lung injury. It was found that survivor alveolar type 2 cells downregulate genes relating to developmental, proliferation and differentiation pathways. Overall design: Bystander and survivor alveolar type 2 cells were isolated from mice using FACs based on tdTomato expression

II型肺泡上皮细胞（Alveolar type 2 cells）在肺损伤后发生增殖。研究表明，存活的II型肺泡上皮细胞会下调与发育、增殖及分化通路相关的基因。整体实验设计：通过基于tdTomato表达的荧光激活细胞分选（FACs）技术，从小鼠体内分离得到旁观者型与存活型II型肺泡上皮细胞。