Left Atrial Drainage Cannula in Bleeding and Thrombosis During ECMO

Left Atrial Drainage Cannula
Study Description
Bleeding and thrombosis represent major adverse events during extracorporeal membrane oxygenation (ECMO). Complications resulting from these events can lead to death or need for long term rehabilitation support. Despite the increasing use of extracorporeal support and new technology which makes it simpler and potentially safer to apply, little scientific information regarding the predictors of bleeding or thrombosis exists.

This project sought to describe the incidence of bleeding and thrombosis in ECMO patients at Collaborative Pediatric Critical Care Research Network (CPCCRN) sites and to describe current anticoagulation monitoring practices. Additionally, it sought evidence of association between bleeding and thrombotic complications, laboratory coagulation measurements, patient characteristics, ECMO circuitry, and adherence to center-specific ECMO management protocols. Data was collected on 514 subjects receiving ECMO at CPCCRN sites over a 21-month period. Data was collected on 514 subjects receiving ECMO at CPCCRN sites over a 21-month period.

左心房引流套管

研究描述

体外膜肺氧合（extracorporeal membrane oxygenation，ECMO）治疗期间，出血与血栓形成为两大主要不良事件。此类并发症可导致患者死亡，或需长期康复支持。尽管体外生命支持技术的应用愈发广泛，且相关新技术可简化操作、提升应用安全性，但目前针对出血或血栓形成预测因素的科学研究资料仍较为匮乏。

本项目旨在明确儿童重症监护合作研究网络（Collaborative Pediatric Critical Care Research Network，CPCCRN）各中心内接受ECMO治疗患者的出血与血栓形成发生率，并梳理当前抗凝监测的临床实践现状。此外，本项目还旨在探究出血与血栓并发症、实验室凝血指标检测结果、患者特征、ECMO循环管路，以及是否遵循各中心专属ECMO管理方案之间的关联证据。本项目在21个月的周期内，收集了CPCCRN各中心共514名接受ECMO治疗受试者的相关数据。本项目在21个月的周期内，收集了CPCCRN各中心共514名接受ECMO治疗受试者的相关数据。