Tn antibody the response to virus infections (A hypothesis)

The human innate anti-A isoagglutinin activity, expressed by polyreactive IgM, is serologically identical to the anti-A activity of C57BL/10 mice and is inhibited by <em>Helix pomatia</em>- and/or Tn-reactive ovarian glycolipids from these animals, which no longer produce the anti-A after early ovariectomy. Thus, the human anti-A antibody does not arise in response to A-allelic (genetic) antigenic activity. While the mouse anti-A antibody, produced together with <em>Helix pomatia</em>- and/or Tn-reactive glycolipids in the autologous ovary and mirrors the egg-protecting function of <em>Helix pomatia</em>-reactive anti-Tn hemagglutinin, the human anti-A most likely reflects nothing more than the monitoring of Tn-associated growth processes and can therefore be considered and referred to as anti-Tn antibody. Moreover, if different viral infections may be inhibited by natural and monoclonal antibodies, regardless of the infected individual’s ABO(H) blood group, it is unlikely that the stimulatory antigenicity is encoded by an A allele; and if additionally, viral serine molecules are essential for viral infections, this antigenicity is most likely a cross-species, mucin-type hybrid <em>O</em>-GalNAcα1-Ser/Thr-R or Tn formation, and the antibody responding to it is anti-Tn-specific, identical to the cross-reactive anti-A isoagglutinin, which ultimately represents another anti-Tn antibody version and a potential response to ubiquitous virus infections.

由多反应性IgM（polyreactive IgM）介导的人类天然抗A同种凝集素活性，在血清学层面与C57BL/10小鼠的抗A活性完全一致，且可被该类动物的<em>Helix pomatia</em>（罗马蜗牛）反应性和/或Tn（Tn抗原）反应性卵巢糖脂所抑制；此类动物在早期卵巢切除后便无法再产生抗A活性。由此可见，人类抗A抗体的产生并非针对A等位基因（遗传性）抗原活性。尽管小鼠抗A抗体可与<em>Helix pomatia</em>反应性及/或Tn反应性糖脂在自体卵巢中共表达，且可模拟<em>Helix pomatia</em>反应性抗Tn血凝素的卵保护功能，但人类抗A抗体很可能仅反映了对Tn相关生长过程的监视作用，因此可被认定并称为抗Tn抗体。此外，若天然抗体与单克隆抗体均可抑制不同类型的病毒感染，且该效应不受感染者ABO(H)血型的影响，则此类刺激性抗原性不太可能由A等位基因编码；进一步而言，若病毒丝氨酸分子对病毒感染至关重要，则该抗原性极有可能为跨物种的黏蛋白型杂合O-GalNAcα1-Ser/Thr-R（即Tn抗原）结构，针对该结构的抗体为抗Tn特异性抗体，与交叉反应性抗A同种凝集素完全一致——而后者本质上是另一种抗Tn抗体形式，亦是对普遍存在的病毒感染的潜在免疫应答。