CIL:36293, Mus musculus, squamous basal cells, juctional squamous cells. In Cell Image Library

Embryonic cell precursors (green) of Barrett’s esophagus at the junction between the stomach and esophagus (red). Barrett's esophagus arrises not from mutant cells in the esophagus but rather a small group of previously overlooked cells in all adults that can rapidly expand to cancer precursors when the normal esophagus is damaged by acid. The red antibody is against keratin 6 expressed on junctional squamous cells, whereas the green antibody is to keratin 7 expressed in embryonic precursors of Barrett's that reside at the junction.

胃食管交界处的巴雷特食管（Barrett's esophagus）胚胎细胞前体以绿色荧光标记，该交界区域的组织以红色荧光标记。巴雷特食管并非起源于食管内的突变细胞，而是源于所有成人体内一组此前被忽视的小型细胞群——当正常食管受到胃酸损伤时，这类细胞可快速增殖为癌前病变细胞。本实验中，红色荧光标记的抗体靶向结合交界部鳞状细胞表达的角蛋白6（keratin 6），而绿色荧光标记的抗体则靶向结合定居于胃食管交界处的巴雷特食管胚胎前体细胞所表达的角蛋白7（keratin 7）。