Ru(II)/Ir(III)-Catalyzed C–H Bond Activation/Annulation of Cyclic Amides with 1,3-Diketone-2-diazo Compounds: Facile Access to 8<i>H</i>‑Isoquinolino[1,2‑<i>b</i>]quinazolin-8-ones and Phthalazino[2,3‑<i>a</i>]cinnoline-8,13-diones

Efficient access to 8H-isoquinolino­[1,2-b]­quinazolin-8-ones and phthalazino­[2,3-a]­cinnoline-8,13-diones through cyclic amide-directed Ru­(II)/Ir­(III)-catalyzed C–H bond activation, has been developed. Consecutive C–H bond activation, carbene insertion, and condensation annulation processes were realized, affording 8H-isoquinolino­[1,2-b]­quinazolin-8-one and phthalazino­[2,3-a]­cinnoline-8,13-dione derivatives in good-to-excellent yields under mild conditions, with H2O and N2 being generated as the only byproducts.本研究开发了一种通过环酰胺导向的钌(II)/铱(III)催化C-H键活化策略，高效制备8H-异喹啉并[1,2-b]喹唑啉-8-酮类化合物与酞嗪并[2,3-a]噌啉-8,13-二酮类化合物。该方法历经连续C-H键活化、卡宾插入及缩合环化过程，在温和反应条件下以良好至优异的收率得到目标衍生物，仅以水和氮气作为唯一副产物。