Transition-Metal-Free Three-Component Reaction: Additive Controlled Synthesis of Sulfonylated Imidazoles

Two
efficient transition-metal-free highly regioselective pathways
for constructing sulfonylated imidazoles via three-component reactions
of amidines, ynals, and sodium sulfonates have been developed. The
generations of different sulfonylated imidazoles were simply controlled
by additives. In addition, this method features environmental friendliness,
good functional group tolerance, and high atom economy, which makes
it practical.

本研究开发了两种无过渡金属（transition-metal-free）参与的高效且高度区域选择性合成路径，可通过脒（amidines）、炔醛（ynals）与磺酸钠盐（sodium sulfonates）的三组分反应构建磺酰化咪唑（sulfonylated imidazoles）。不同磺酰化咪唑类产物的生成可通过添加剂进行简便调控。此外，该方法具备环境友好、官能团耐受性优异、原子经济性高等优势，具有良好的实用价值。