Suzuki–Miyaura Coupling of Aryl Iodides, Bromides, and Chlorides Catalyzed by Bis(thiazole) Pincer Palladium Complexes

Bis­(thiazole) pincer palladium complexes showed efficient
catalytic
activity for the Suzuki–Miyaura coupling of aryl halides, allowing
the synthesis of biaryls with very high turnover numbers and turnover
frequencies. The complexes were successfully applied in the scalable
and green synthesis of the key intermediates of bioactive LUF5771
and its analogues.

双(噻唑)钳形钯配合物展现出高效的催化活性，可催化芳基卤化物的铃木-宫浦偶联反应（Suzuki–Miyaura coupling），能够以极高的周转数（turnover number）与周转频率（turnover frequency）合成联芳烃类化合物。该类配合物已成功应用于生物活性化合物LUF5771及其类似物关键中间体的可规模化绿色合成。