Supplementary Material for: Comparison of Hospital Anxiety and Depression Scale (HADS) and Zung Self-Rating Anxiety/Depression Scale (SAS/SDS) in Evaluating Anxiety and Depression in Patients with Psoriatic Arthritis

<b><i>Background:</i></b> This study aimed to compare the Hospital Anxiety and Depression Scale (HADS) and the Zung Self-Rating Anxiety/Depression Scale (SAS/SDS) in evaluating anxiety and depression in psoriatic arthritis (PsA) patients. <b><i>Methods:</i></b> A total of 70 PsA patients were enrolled. Demographic and clinical characteristics were collected after enrollment. HADS-A and SAS were used to evaluate the anxiety of PsA patients, while HADS-D and SDS were used to evaluate the depression of PsA patients. <b><i>Results:</i></b> Similar results were observed in detecting the rate of anxiety by HADS-A and SAS (27.1 vs. 21.4%, <i>p</i> = 0.424), and there was no difference in classifying the severity of anxiety by HADS-A and SAS (<i>p</i> = 0.347). The Spearman test also disclosed that HADS-A score was positively associated with SAS score (<i>p &lt;</i>0.001). The rates of depression were similar by HADS-D and SDS (27.1 vs. 40.0%; <i>p</i> = 0.108). However, different results were observed in grading the severity of anxiety by HADS-D and SDS (<i>p</i> = 0.009), and no correlation was observed between HADS-D and SDS scores (<i>p</i> = 0.138). The consumption of time for HADS assessment was shorter than that for SAS/SDS assessment (<i>p</i> &lt; 0.001). In addition, a positive correlation of HADS-A score with patients’ global assessment (PGA) (<i>p</i> = 0.022) and fatigue scores (<i>p</i> = 0.028) was discovered, and HADS-D score was positively associated with PGA score (<i>p</i> = 0.019). SAS or SDS score presented less correlation with clinical features of PsA patients, which illuminated that only SAS score was positively associated with duration of psoriasis (<i>p</i> = 0.030). <b><i>Conclusion:</i></b> HADS seems to be a better option for anxiety and depression assessment than SAS/SDS in PsA patients.

**背景：** 本研究旨在比较医院焦虑抑郁量表（Hospital Anxiety and Depression Scale, HADS）与宗氏自评焦虑/抑郁量表（Zung Self-Rating Anxiety/Depression Scale, SAS/SDS）在评估银屑病关节炎（psoriatic arthritis, PsA）患者焦虑与抑郁状态中的应用效果。**方法：** 本研究共纳入70例银屑病关节炎患者。入组后收集患者的人口学特征与临床特征数据。采用医院焦虑抑郁量表焦虑亚量表（HADS-A）与宗氏自评焦虑量表（SAS）评估银屑病关节炎患者的焦虑状态，采用医院焦虑抑郁量表抑郁亚量表（HADS-D）与宗氏自评抑郁量表（SDS）评估其抑郁状态。**结果：** HADS-A与SAS检测焦虑检出率的结果相近（27.1% vs. 21.4%，*p*=0.424），二者在焦虑严重程度分级上无统计学差异（*p*=0.347）。斯皮尔曼相关性检验显示，HADS-A评分与SAS评分呈显著正相关（*p*<0.001）。HADS-D与SDS检测抑郁检出率的结果亦无显著统计学差异（27.1% vs. 40.0%；*p*=0.108），但二者在抑郁严重程度分级上结果存在显著差异（*p*=0.009），且HADS-D评分与SDS评分无显著相关性（*p*=0.138）。HADS量表的评估耗时显著短于SAS/SDS量表（*p*<0.001）。此外，研究发现HADS-A评分与患者整体评估（Patient Global Assessment, PGA）评分（*p*=0.022）及疲劳评分（*p*=0.028）均呈显著正相关，HADS-D评分与PGA评分亦呈显著正相关（*p*=0.019）。SAS或SDS评分与银屑病关节炎患者的临床特征相关性较弱，仅SAS评分与银屑病病程呈显著正相关（*p*=0.030）。**结论：** 相较于SAS/SDS量表，医院焦虑抑郁量表（HADS）或是评估银屑病关节炎患者焦虑与抑郁状态的更优选择。