Fecal metagenome dataset of 48 healthy women. Fecal metagenome dataset of healthy women living in high-altitude and sea-level areas

Gut microbiota acts as an important complementary role in human health and is shaped by diverse factors including ethnicity, dietary pattern, and surrounding environmental factors. However, the effect of high-altitude environments on the human gut microbiota is rarely investigated. Herein, we characterized the gut microbiota of 30 and 18 healthy individuals living in sea level and high-altitude areas, respectively, using deep whole-metagenome shotgun sequencing of their fecal samples. The results in this pilot study provided pieces for understanding the underlying mechanisms of high-altitude geographic adaptation of the human gut microbiome.

肠道菌群 (gut microbiota) 在人体健康中发挥关键辅助功能，其组成受种族、饮食模式与周边环境等多种因素共同塑造。然而，高海拔环境对人体肠道菌群的影响却鲜有相关研究。本研究中，我们针对分别居住于海平面地区与高海拔地区的30名及18名健康个体，通过对其粪便样本开展深度全宏基因组鸟枪法测序，解析了两组人群的肠道菌群特征。本项预实验的研究结果，为阐释人体肠道微生物组 (gut microbiome) 的高海拔地理适应性潜在机制提供了重要线索。