FAIRsharing record for: GeneNet Engine

This FAIRsharing record describes: GeneNet Engine is an exploratory tool to aid hypothesis and biomarker development at a systems-level for genotype-phenotype relationships. Expressed phenotypes may arise due to interactions between multiple genes in a system and effects from the surrounding environment. Therefore, a high systems-level view is needed to identify gene sets causal for a trait. The ability to predict genes that effect important traits is of great importance to agriculture and health. System biology approaches, that combine genomics, gene co-expression networks and data from genetic studies help provide a view at the systems-level of gene interactions. As co-expressed genes tend to be involved in similar processes, it is expected that co-expressed genes may work together to give rise to specific pheontypes. The network module serves as the basic unit of exploration in this site.

本FAIRsharing记录对以下内容进行说明：GeneNet Engine是一款面向基因型-表型关联研究的系统级探索工具，用于辅助假说构建与生物标志物（biomarker）开发。表达型表型的产生往往源于系统内多基因间的相互作用，以及周边环境带来的影响。因此，若要识别出对某一性状具有因果调控作用的基因集，需具备系统级的全局视野。预测调控重要性状基因的能力，对农业与健康领域均具有极高的应用价值。系统生物学（systems biology）方法整合基因组学、基因共表达网络与遗传研究数据，能够为研究者提供基因互作的系统级视角。由于共表达基因通常参与相似的生物学过程，因此可推测，共表达基因可协同作用，进而产生特定的表型。网络模块为本平台的基础探索单元。