Palladium-Catalyzed Amination/Dearomatization Reaction of Indoles and Benzofurans

This report describes
a palladium-catalyzed dearomatization and
amination tandem reaction of 2,3-disubstituted indoles and benzofurans
via the Catellani strategy. This reaction provides a new method for
the construction of amino-substituted indoline-fused cyclic and benzofuran
spiro compounds in good yields. The reaction has broad functional
group compatibility and substrate scope.

本报告阐述了采用卡泰拉尼（Catellani）策略的钯催化2,3-二取代吲哚与苯并呋喃的去芳构化-胺化串联反应。该反应可通过优异收率实现氨基取代吲哚啉稠环类及苯并呋喃螺环类化合物的构建，为这类分子的合成提供了全新途径。该反应具备宽泛的官能团兼容性与底物适用范围。