Interim Dataset for the DIssemination of REgistered COVID-19 Clinical Trials (DIRECCT) Study

The DIRECCT study is a multi-phase, living examination of clinical trial results dissemination throughout the COVID-19 pandemic.

Currently the data for Phase 1 are available. Phase 1 of the project examined trials completed during the first six months of the pandemic (i.e., through 30 June 2020). Data were collected using a combination of automated and manual strategies; automated searches were performed on 30 June 2020, and manual searches were performed between 21 October 2020 and 18 January 2021.

The data for the study are split into three datatables: `trials`, `registrations`, and `results`. The three datatables can be treated as relational and joined on the `id` column. Variables are documented in `data-dictionary`.  

Data sources for `trials` and `registrations` include the International Clinical Trials Registry Platform (ICTRP) list of registered COVID-19 studies, and individual clinical trial registries; data from these sources were curated and cleaned through the COVID-19 TrialsTracker project (https://covid19.trialstracker.net/). Some of the trial data included in the dataset are provisional and have not been systematically quality controlled (e.g., data on interventions); this is noted in the data dictionary when applicable. Data sources for `results` include information on trial results located from our automated and manual searches in the COVID-19 Open Research Dataset (CORD-19), PubMed, EuropePMC, Google Scholar, Google, and registries.

Additional information on the project is available at the project's OSF page: https://doi.org/10.17605/osf.io/5f8j2.

DIRECCT研究是一项多阶段动态追踪研究，旨在全面梳理新冠疫情期间临床试验结果的传播情况。

目前该研究第一阶段的数据已公开可用。本研究第一阶段聚焦于疫情暴发后的前六个月（即截至2020年6月30日）完成的临床试验。数据采集采用自动化与人工结合的策略：自动化检索于2020年6月30日完成，人工检索则于2020年10月21日至2021年1月18日期间开展。

本研究的数据分为三张数据表：`trials`、`registrations`与`results`。三张数据表具备关联关系，可通过`id`字段进行关联连接。变量说明详见`data-dictionary`（数据字典）。

`trials`与`registrations`的数据来源包括国际临床试验注册平台（International Clinical Trials Registry Platform, ICTRP）发布的新冠注册研究清单，以及各独立临床试验注册平台；上述来源的数据均经新冠临床试验追踪项目（COVID-19 TrialsTracker，https://covid19.trialstracker.net/）整理并清洗。本数据集包含的部分临床试验数据为临时性数据，尚未经过系统性质量管控（如干预措施相关数据），此类情况将在适用时于数据字典中予以注明。

`results`的数据来源包括通过自动化与人工检索在新冠开放研究数据集（COVID-19 Open Research Dataset, CORD-19）、PubMed、欧洲PubMed中心（EuropePMC）、谷歌学术（Google Scholar）、谷歌（Google）以及各临床试验注册平台中获取的临床试验结果相关信息。

有关本项目的更多详细信息可查阅其开放科学框架（Open Science Framework, OSF）页面：https://doi.org/10.17605/osf.io/5f8j2。