Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers

Esophageal squamous cell carcinomas (ESCC) is one of the most commonly diagnosed cancers and is a lethal cancer with poor outcome. In this study, we performed whole-genome sequencing (WGS) in tumor tissues and matched adjacent noncancerous specimens from ESCC patients with the corresponding clinical information collected. Our study illustrated the landscape of genomic alterations from a comprehensive perspective .

食管鳞状细胞癌（Esophageal squamous cell carcinomas, ESCC）是最常见的确诊恶性肿瘤之一，亦是预后极差的致死性癌症。本研究针对食管鳞状细胞癌患者的肿瘤组织及配对癌旁正常标本开展了全基因组测序（whole-genome sequencing, WGS），并收集了对应的临床信息。本研究从综合视角系统阐明了基因组变异的全景图谱。