miRNA expression data from human cell lines (Panc1 cells). Homo sapiens

The experiment aims to identify miRNAs that are regulated in response to TRAIL R1 si-RNA and TRAIL R2 si-RNA. The overall aim of the study was to identify mechanisms by which TRAIL death receptors may contribute to malignancy via inhibition of let-7 maturation. Overall design: Comparison of TRAIL R1 si-RNA vs. control si-RNA and comparison of TRAIL R2 si-RNA vs. control

本实验旨在鉴定受肿瘤坏死因子相关凋亡诱导配体受体1（TRAIL R1）小干扰RNA（si-RNA）与肿瘤坏死因子相关凋亡诱导配体受体2（TRAIL R2）小干扰RNA（si-RNA）调控的微RNA（miRNAs）。本研究的总体目标为阐明肿瘤坏死因子相关凋亡诱导配体（TRAIL）死亡受体通过抑制let-7的成熟过程，进而参与恶性病变发生的潜在分子机制。实验设计：设置两组对照比较实验，分别为TRAIL R1小干扰RNA组与对照小干扰RNA组，以及TRAIL R2小干扰RNA组与对照小干扰RNA组。