Basic information about the included literature.

ObjectiveThis study conducts a rigorous meta-analysis of existing literature to rigorously examine the efficacy of Proprioceptive Neuromuscular Facilitation (PNF) in ameliorating functional deficits associated with Chronic Ankle Instability (CAI).MethodsLiterature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biology Medicine disc (CBM), PubMed, EBSCO (Medline, CINAHL, SPORTDiscus, and Rehabilitation & Sports Medicine Source), Embase, ScienceDirect, ProQuest, Cochrane Library, and Web of Science for randomized controlled trials assessing the effects of Proprioceptive Neuromuscular Facilitation interventions on patients with Chronic Ankle Instability. The publication timeframe spanned from the inception of each database until April 10, 2024. Meta-analysis was performed using STATA 12 software on the included studies.Results① A total of 12 randomized controlled trials were included, encompassing 405 patients with Chronic Ankle Instability, demonstrating a generally high methodological quality of the literature.② Meta-analysis results indicate that compared to the control group, Proprioceptive Neuromuscular Facilitation (PNF) significantly enhanced the balance ability of patients with Chronic Ankle Instability as measured by the Y Balance Test (YBT) (Weighted Mean Difference (WMD) = 3.61, 95% CI [2.65, 4.56], z = 7.42, P0.05), however, the effects of PNF training persisted for a certain period even after cessation of treatment.ConclusionProprioceptive Neuromuscular Facilitation (PNF) can significantly improve balance, muscle strength, and pain in patients with Chronic Ankle Instability (CAI). While PNF has shown improvements in joint position sense and dorsiflexion range of motion for CAI patients, with effects that remain for a period thereafter, these improvements were not significantly different when compared to the control group. Further research is required to substantiate these specific effects.### 研究目的 本研究针对现有文献开展严格的元分析，以严谨考察本体感觉神经肌肉促进法(Proprioceptive Neuromuscular Facilitation, PNF)对改善慢性踝关节不稳(Chronic Ankle Instability, CAI)相关功能缺损的临床疗效。 ### 研究方法 本研究在多个数据库中开展文献检索，包括中国知网(China National Knowledge Infrastructure, CNKI)、维普(VIP)、万方、中国生物医学文献数据库(China Biology Medicine disc, CBM)、PubMed、EBSCO(含Medline、CINAHL、SPORTDiscus及Rehabilitation & Sports Medicine Source)、Embase、ScienceDirect、ProQuest、Cochrane图书馆及Web of Science，检索时限为各数据库建库起至2024年4月10日，纳入评估本体感觉神经肌肉促进法干预对慢性踝关节不稳患者疗效的随机对照试验。本研究采用STATA 12软件对纳入的研究进行元分析。 ### 研究结果 ① 最终纳入12项随机对照试验，共包含405例慢性踝关节不稳患者，纳入文献的方法学质量整体较高。 ② 元分析结果显示：与对照组相比，以Y平衡测试(Y Balance Test, YBT)为评估指标时，本体感觉神经肌肉促进法(PNF)可显著提升慢性踝关节不稳患者的平衡能力，加权均数差(Weighted Mean Difference, WMD)=3.61，95%置信区间(Confidence Interval, CI)为[2.65, 4.56]，z=7.42，P<0.05；但即便在干预停止后，PNF训练的效应仍可维持一段时间。 ### 研究结论 本体感觉神经肌肉促进法(PNF)可显著改善慢性踝关节不稳(CAI)患者的平衡能力、肌肉力量及疼痛症状。尽管PNF可改善慢性踝关节不稳患者的关节位置觉与踝关节背屈活动度，且该改善效应可维持一段时间，但与对照组相比，上述改善并未达到统计学显著性差异，仍需开展进一步研究以验证此类特定效应。