Vaginal metagenome dataset of 47 healthy women. Vaginal metagenome dataset of healthy women living in high-altitude and sea-level areas

The vaginal microbiota plays an important role in the health of the female reproductive tract and is closely associated with a variety of pregnancy outcomes and sexually transmitted diseases. A variety of internal and external factors (such as geography, ethnicity, and diet) have a strong influence on the changes in a woman's vaginal microbiome. The effect of a high-altitude living environment on female vaginal microbiota has not been described. In this study, we characterized the vaginal bacteriome and virome of 13 and 34 healthy women living in high-altitude and sea-level areas, respectively, using whole-metagenome shotgun sequencing of their vaginal mucus samples.

阴道微生物群（vaginal microbiota）在女性生殖道健康中发挥重要作用，且与多种妊娠结局及性传播疾病密切相关。诸多内外因素（如地理、种族与饮食）均可对女性阴道微生物组的变化产生显著影响。目前，尚无关于高海拔居住环境对女性阴道微生物群影响的相关研究报道。本研究通过对阴道黏液样本进行全宏基因组鸟枪测序（whole-metagenome shotgun sequencing），分别对13名高海拔地区健康女性与34名海平面地区健康女性的阴道细菌组（vaginal bacteriome）及病毒组（virome）开展了特征分析。