Table_2_Risk Factors for Physical Function Impairments in Postintensive Care Syndrome: A Scoping Review.docx

ObjectiveSurvivors of critical illness may experience short- and long-term physical function impairments. This review aimed to identify the risk factors for physical function impairments from the current literature.
Data SourcesA systematic search of the PubMed, Embase, Web of Science, and Cochrane Library databases following the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews guideline was performed.
Study SelectionThe risk factors reported in all human studies reporting physical function impairments in children admitted to the pediatric intensive care unit (PICU) were reviewed and categorized. Two investigators independently screened, evaluated, and selected studies for inclusion. Data from eligible studies were extracted by one investigator, and another investigator reviewed and verified the data. A systematic narrative approach was employed to review and summarize the data.
ResultsA total of 264 studies were found to be eligible, with 19 studies meeting the inclusion criteria. Children admitted to the PICU experienced physical function impairments during their stay, which can last for years. The studies varied primarily in the measurement timing and tools used. The most frequently reported risk factors for physical function impairments were age, race or ethnicity, a pre-admission chronic condition, sex, disease severity, duration or the presence of mechanical ventilation, and admission diagnosis.
ConclusionsPhysical function impairments may be persistent in PICU survivors. To prevent these impairments in critically ill patients, pediatricians should pay attention to modifiable risk factors, such as the duration of mechanical ventilation. Future studies need to promote a combination of standardized measures for the detection and prevention of physical function impairments.

研究目的：重症疾病幸存者可能出现短期及长期的躯体功能损害。本综述旨在从现有文献中挖掘与躯体功能损害相关的危险因素。
数据来源：本研究遵循《系统评价与Meta分析范围综述扩展版首选报告条目》（Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews）指南，对PubMed、Embase、Web of Science及Cochrane Library数据库开展系统性检索。
研究筛选：本综述对所有报道儿科重症监护室（Pediatric Intensive Care Unit, PICU）收治儿童躯体功能损害的人体研究中提及的危险因素进行梳理与分类。由2名研究人员独立完成研究的筛选、评估与纳入决策；1名研究人员提取符合纳入标准的研究数据，另1名研究人员对数据进行复核与验证。本研究采用系统性叙事法对数据进行梳理与总结。
研究结果：本研究共检索到264项符合初步筛选标准的研究，其中19项满足最终纳入标准。PICU收治儿童在住院期间即可出现躯体功能损害，且该损害可迁延数年。纳入研究的主要差异体现在评估时机与评估工具的选择上。被最频繁报道的躯体功能损害危险因素包括：年龄、种族/民族、入院前慢性疾病史、性别、疾病严重程度、机械通气时长或是否实施机械通气，以及入院诊断。
结论：PICU幸存者的躯体功能损害可能持续存在。为预防重症患者出现此类损害，儿科医师应关注可干预的危险因素，例如机械通气时长。未来的研究应推广采用标准化的躯体功能损害检测与预防联合方案。