Integrative metabolomic and transcriptomic analysis reveals difference in glucose and lipid metabolism in the longissimus muscle of Luchuan and Duroc pigs

In this study, the metabolic and transcriptomic profiles of longissimus dorsi muscle from Duroc and Luchuan pigs were compared. A total of 609 metabolites were identified, 77 of which were significantly decreased in Luchuan compared to Duroc, and 71 of which were significantly elevated. Most differentially accumulated metabolites (DAMs) upregulated in Luchuan were glycerophospholipids, fatty acids, oxidized lipids, alcohols, and amines, while metabolites downregulated in Luchuan were mostly amino acids, organic acids and nucleic acids, bile acids and hormones.

本研究对杜洛克猪（Duroc）与陆川猪（Luchuan）的背最长肌（longissimus dorsi muscle）代谢组学与转录组学谱开展了比较分析。本次研究共鉴定得到609种代谢物，其中相较于杜洛克猪，陆川猪中有77种代谢物显著下调，71种显著上调。陆川猪中上调的差异累积代谢物（differentially accumulated metabolites, DAMs）主要包括甘油磷脂、脂肪酸、氧化脂质、醇类及胺类；而陆川猪中下调的代谢物则多为氨基酸、有机酸、核酸、胆汁酸及激素。