Catalytic and Atom-Economic Intermolecular Amidoselenenylation of Alkenes

A method for the simple, efficient, and atom-economic amidoselenenylation of simple alkenes under mild conditions using TiCl4 as a catalyst and N-(phenylseleno)­phthalimide as both a nitrogen and selenium source was developed. A broad range of olefins can be applied to afford vicinal amidoselenides in good yield and with high regioselectivity and diastereoselectivity.本研究开发了一种以四氯化钛(TiCl4)为催化剂、N-(苯基硒代)邻苯二甲酰亚胺[N-(phenylseleno)phthalimide]同时作为氮源与硒源，在温和反应条件下实现简单烯烃简便、高效且原子经济性酰胺硒化的方法。该方法可适配多种烯烃底物，能够以良好收率制备邻位酰胺硒化物产物，且展现出优异的区域选择性与非对映选择性。